Sickle Cell

SICKLE CELL ANEMIA Introduction Sickle stall disease is a elementric term for a group of brokertic effort caused by the ?-globin ingredient called reap hook hemoglobin (Hb S) (Kock et al., 2000). The ?-globin gene is located on the short arm of chromosome 11, and it is a particle of the globin gene family involved in oxygen becharm (Koch et al., 2000). Sickle cubicleular teleph atomic number 53 disease is the about roughhewn ace gene disorder in black Americans, and is also common in persons from Mediterranean countries, Turkey, the Arabian Peninsula, Caribbean, and the Indian subcontinent (Wethers, 2000). It is estimated that more than 50,000 Americans are affected with reaping hook cubicle disease, making this disease a one of the well-nigh prevalent genetic disorders in the united States (Kock et al., 2000). There are several forms of sickle carrel disease, and the most common forms are sickle carrel anemia, the sickle ß-thalassemia syndromes, and hemoglobinopathies (Wethers, 2000). In sickle cell anemia, also called homozygous sickle cell disease (or SS disease), the individual inherits a sickle (S) gene from severally parent (Wethers, 2000). In the sickle ß-thalassemias, individuals have a sickle (S) gene and gene for ß-thalassemia (Wethers, 2000).

In hemoglobinopathies or doubly heterozygous sickle cell disease, the sickle (S) gene is associated with a nonher kinky hemoglobin, such as C, D, G or O (Wethers, 2000). The make of sickle cell disease vary greatly from one person to the next. just about affected people rarely are ill opus o thers are frequently hospitalized. In contra! st to this disease, there is the author in which an individual behave a normal gene (A) in association with the sickle (S) gene. This carrier state is referred to as a sickle cell trait and these individuals: (i) are protect from malaria infection (Aluoch, 1997), (ii) do not express sickle cell disease unless under whimsical circumstances such as marked hypoxia (National Institute of wellness [NIH], 1996), and (iii) can pass the...If you exigency to get a in full essay, order it on our website: BestEssayCheap.com

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